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What Are Silent Information Regulator Genes and How Do They Affect Your Lifespan?

Silence information regulator genes, also known as SIR or Sirtuins, are found across multiple species and are thought to contribute to regulation of fat storage, low blood cholesterol, low blood glucose levels, and low insulin levels. Sirtuins's regulation of these important health indicators is assumed to be an important part of the explanation for why caloric restriction increases lifespan.

In a paper published in Nature, 2001 Heidi Tissenbaum and Leonard Guarante reported that nematode worms (c. elegans) experienced increased lifespans of 50-100% when injected with certain genetic fragments of sirtuins. These results echoed similar findings in experiments with yeast strains. Tissenbaum and Guarante hypothesize that sirtuins regulate insulin which decreases blood glucose levels.

Interestingly worms treated with a complete suppression of the same sirtuins lived much shorter lives, adding evidence to the importance of blood sugar regulation in human aging.

One might conclude that eating low GI foods like vegetables, and fruits, can extend life span, however, it is a giant leap to go from experiments on yeast and flat worms to making conclusions about humans. That said, it certainly can’t hurt to strive for a low glycemic diet by eliminating sugar-rush foods.

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References

  • Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans.Tissenbaum HA, Guarente L.,Nature. 2001 Mar 8;410(6825):227-30

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